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2 edition of Quantitative studies of desensitisation in guinea-pig anaphylaxis. found in the catalog.

Quantitative studies of desensitisation in guinea-pig anaphylaxis.

David Tinakpo"evwan Okpako

Quantitative studies of desensitisation in guinea-pig anaphylaxis.

by David Tinakpo"evwan Okpako

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  • 40 Currently reading

Published in Bradford .
Written in English


Edition Notes

Ph.D. thesis. Typescript.

SeriesTheses
The Physical Object
Pagination1 vol
ID Numbers
Open LibraryOL13729189M

Prostaglandins (Pgs), slow-reacting substance of anaphylaxis (SRS-A), and histamine were released from anaphylactic isolated perfused guinea pig hearts. Pgs were to the greatest part of the F 2α -type. The quantitative release of histamine and slow reacting substance by specific antigen from perfused, chopped, sensitized guinea pig lung has been used to study the opposing effects of monobasic and certain dibasic fatty acids on the anaphylactic reaction.

The quantitative release of histamine by specific antigen from perfused, chopped, sensitized guinea pig lung has been used to study the effect of peptidase substrates and inhibitors on the anaphylactic reaction. The anaphylactic release of histamine is prevented by chymotrypsin substrates and inhibitors but not by trypsin, carboxypeptidase, or leucine aminopeptidase substrates or the soybean. The emergence of egg allergy has had both industrial and clinical implications. In industrialized countries, egg allergy accounts for one of the most prevalent food hypersensitivities, especially in children. Atopic dermatitis represents the most common clinical manifestation in infancy; however, the range of clinical signs is broad and encompasses life-threatening anaphylaxis. The dominant.

In the present study we investigated desensitization phenomena of guinea‐pig jejunal longitudinal smooth muscle responses after stimulation with μ m histamine or methacholine, using a superfusion method. 2. Histamine H 1 ‐receptor‐mediated contractions appear to be rapidly reduced after application of μ m histamine. Quantitative studies of complement fixation. I- A simplified and accurate procedure based on 50 per cent hemolytic end point. Rev. Inst. Med. Trop. São Paulo , A simplified formula for the production of diphtheric toxin of high potency (50Lf). Rev. Bras. Biol. 3(3),


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Quantitative studies of desensitisation in guinea-pig anaphylaxis by David Tinakpo"evwan Okpako Download PDF EPUB FB2

Studies of desensitization indicate that the progressive decrease in sensitivity to repeated administrations of the same dose of antigen follows an exponential pattern. It is suggested that this approach might form a basis for reliable quantitative investigations of anaphylactic by: 5.

Studies of desensitization indicate that the progressive decrease in sensitivity to repeated administrations of the same dose of antigen follows an exponential pattern. It is suggested that this approach might form a basis for reliable quantitative investigations of anaphylactic phenomena.

Br J Pharmacol Chemother. Dec; QUANTITATIVE EVALUATION OF GUINEA-PIG ANAPHYLAXIS IN VIVO. HICKS R, LEACH GD.

Two methods for recording bronchoconstrictor responses to antigen injected into sensitized guinea-pigs have been used to show that the dose/response relationship is a normal pharmacological one characterized by a sigmoid curve. Studies of desensitization Cited by: 5. Quantitative evaluation of guinea-pig anaphylaxis in vivo.

Studies of desensitization indicate that the Quantitative studies of desensitisation in guinea-pig anaphylaxis. book decrease in sensitivity to repeated administrations of the same dose of antigen follows an exponential pattern. It is suggested that this approach might form a basis for reliable quantitative investigations of anaphylactic Author: R.

Hicks and G. Leach. Quantitative evaluation of guinea-pig anaphylaxis in vivo. Studies of desensitization indicate that the progressive decrease in sensitivity to repeated administrations of the same dose of antigen follows an exponential pattern.

It is suggested that this approach might form a basis for reliable quantitative investigations of anaphylactic. STUDIES IN GUINEA PIG ANAPHYLAXIS WITH THE HOUSE DUST ANTIGEN HAROLD J. FRIEDMAN, M.D, CLEVELAND, OHIO THE nature and source of house dust antigen has been the subject investigations.

Opinion as to the essential character of Author: Harold J. Friedman. The quantitative release of histamine and slow reacting substance by specific antigen from perfused, chopped, sensitized guinea pig lung has been used to study the opposing effects of monobasic. DESENSITIZATION WITH HAPTENS Role of Molecular Size in Specific Precipitation, Anaphylaxis, and Desensitization With Dextran Fractions Budolf Hoene, M.D., Ph.D.,* Oscar Saaineford, Jr., M.D.,** and Susan Quelch, B.S., Charlottesville, Va.

SNSITIZED ANIMALs have been made tolerant of multiples of normally fatal Edoses of allergens in a variety of ways, all of which were transient.

There are definite thresholds of effective concentrations of hapten aerosols. Desensitization may be readily- produced by specific hapten aerosol, in minutes. Aerosol desensitization is local: i.e., subsequent intravenous hapten will cause prompt anaphylaxis. Quantitative factors have not.

*DHC-BA inbred guinea pigs were used. tNot done. controls were run. A standard known fresh-frozen (0C) guinea pig serum control was also run with each assay. To determine C5op a similar assay was performed in which diluted guinea pig serum. The quantitative release of histamine by specific antigen from perfused, chopped, sensitized guinea pig lung has been used to study the effect of peptidase substrates and inhibitors on the anaphylactic reaction.

The similarities and differences between immune hemolysis and anaphylaxis in chopped guinea pig lung are considered in detail. Quantitative Immunochemical Aspects of Some Allergie Reactions* ELVIN A. KABAT, Ph.D. New York, New York WHILE the concept of allergie reac- tions as caused by the combination of antigen with antibody in the tissues is unequivocally established (for earlier studies,1'5) knowledge of the severity of the allergic response as a function of the amounts of antigen and antibody involved is quite.

Acknowledgement--We thank Dr Jos6 de Castillo for reading the manuscript and helpful comments. Chicken-like passive anaphylaxis REFERENCES Benacerraf B. and Kabat E. () A quantitative study of passive anaphylaxis in the guinea pig V.

The latent period in passive anaphylaxis and its relation to the dose of rabbit anti-ovalbumin. The quantitative release of histamine by specific antigen from perfused, chopped, sensitized guinea pig lung has been used to study the effect of peptidase substrates and inhibitors on the.

OVARY Z, BIER OG. Quantitative study of Arthus reaction and of cutaneous anaphylaxis induced passively in the rat. Proc Soc Exp Biol Med. Dec; 81 (3)– OVARY Z, BIER OG. Quantitative studies on passive cutaneous anaphylaxis in the guinea pig and its relationship to the Arthus phenomenon.

J Immunol. Jul; 71 (1):6– OVARY Z. [Quantitative studies in passive cutaneous anaphylaxis of the guinea pig]. Int Arch Allergy Appl Immunol. ; 3 (2)– OVARY Z, BIER OG. Quantitative studies on passive cutaneous anaphylaxis in the guinea pig and its relationship to the Arthus.

BLOCH KJ, KOURILSKY FM, OVARY Z, BENACERRAF B. Properties of guinea pig 7S antibodies. III. Identification of antibodies involved in complement fixation and hemolysis.

J Exp Med. Jun 1; – [PMC free article] BOREUS LO. Quantitative studies on the anaphylactic mastcell reaction in vivo in the guinea pig. Risk of anaphylaxis in a hospital population in relation to the use of various drugs: an international study; International Collaborative Study of Severe Anaphylaxis Article Apr W.H.

Schultz,Physiological Studies in Anaphylaxis, I. The Reaction of Smooth Muscle of the Guinea-Pig Sensitized with Horse Serum, J. Pharmac. exp. Ther.1, – (). Google Scholar. The quantitative release of histamine by specific antigen from perfused, chopped, sensitized guinea pig lung has been used to study the effect of peptidase substrates and inhibitors on the anaphylactic reaction.

The anaphylactic release of histamine is prevented by chymotrypsin substrates and inhibitors but not by trypsin, carboxypeptidase, or. Thc mechanism of anaphylaxis: Specificity of antigen-induced mast cell damage in anaphyla~is in the guinea pig Effect of adrenocorticotropic hormone on anaph>-laxis in the guinea pig Jan Otto, R., and O.

G. Bier: Quantitative study of Arthus reaction and of cutaneous anaphylaxis induced passively in the rat. Proc. Soc. exp. Biol. (N. Y.) 81, (). Google Scholar Otto, R., and O. G. Bier: Quantitative studies on passive cutaneous anaphylaxis in the guinea pig and its relationship to the Arthus phenomenon.OVARY Z.

Reverse passive cutaneous anaphylaxis in the guinea pig with horse, sheep or hen antibodies. Immunology. Jan; – [PMC free article] OVARY Z, BIER OG.

Quantitative studies on passive cutaneous anaphylaxis in the guinea pig and its relationship to the Arthus phenomenon. J Immunol. Jul; 71 (1):6–